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Rituximab has become a mainstay in the therapy of a broad variety of b cell malignancies.
Rituximab moa. The antibody is an igg1 kappa immunoglobulin containing murine light and heavy chain variable region sequences and human constant region sequences fda label. Rituximab may cause a serious brain infection that can lead to disability or death. Hbv reactivation can occur in patients treated with rituximab containing products including rituxan hycela in some cases resulting in fulminant hepatitis hepatic failure and death. Call your doctor right away if you have problems with speech thought vision or muscle movement.
Hepatitis b virus hbv reactivation. Treatment with rituximab at standard weekly dosing is effective in more than 50 of patients with relapsed or refractory cd20 positive follicular non hodgkins lymphoma but is not curative. Rituximab a chimeric monoclonal antibody targeted against the pan b cell marker cd20 was the first monoclonal antibody to be approved for therapeutic use. Rituximab is a chimeric monoclonal antibody against the protein cd20 which is primarily found on the surface of immune system b cells.
In some b cell malignancies rituximab alone can induce high response rates and long term remissions 1 2 while in others adding rituximab to chemotherapy enhances the complete response long term remission and cure rate 3 4. When it binds to this protein it triggers cell death.
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